Concepedia

Biased Agonism

Biased Agonism is a pharmacological phenomenon in cell surface receptor signaling wherein a ligand preferentially activates a specific intracellular signaling pathway over others mediated by the same receptor, thereby eliciting a selective downstream physiological response.

198

Publications

12.5K

Citations

1.3K

Authors

423

Institutions

Publications per year

2017–2026

116

Variants

Signaling Bias

Parents

Publications

198

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

Francis S. Willard, Jonathan D. Douros, M Gabe et al. · JCI Insight · 2020 · 487 citations · Full text

, , +17

A Unified View of “How Allostery Works”

Chung‐Jung Tsai, Ruth Nussinov · PLoS Computational Biology · 2014 · 415 citations · Full text

, , +13

Quantifying Ligand Bias at Seven-Transmembrane Receptors

Sudarshan Rajagopal, Seungkirl Ahn, David H. Rominger et al. · Molecular Pharmacology · 2011 · 390 citations

, , +17

Outcomes of conduct problems in adolescence: 40 year follow-up of national cohort

Ian Colman, Joseph Murray, R. A Abbott et al. · BMJ · 2009 · 384 citations · Full text

, , +16

Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

Alexander Gillis, Arisbel B. Gondin, Andrea Kliewer et al. · Science Signaling · 2020 · 365 citations · Full text

, , +17

1–5 of 198

Authors

1.3K

  1. AC
    Arthur Christopoulos

    Monash University, Australia

    15 publications · 1.2K citations

    14

    h-index

  2. PM
    Patrick M. Sexton

    Monash University, Australia

    12 publications · 1K citations

    12

    h-index

  3. JR
    J. Robert Lane

    Monash University, Australia

    9 publications · 1.1K citations

    9

    h-index

  4. SR
    Sudarshan Rajagopal

    Duke Medical Center, United States

    8 publications · 869 citations

    9

    h-index

  5. DW
    Denise Wootten

    Monash University, Australia

    8 publications · 488 citations

    8

    h-index

1–5 of 1.3K

Institutions

423

  1. Monash University

    Melbourne, Australia

    23 h-index

    159 publications

    12.8K citations

  2. Duke University

    Durham, United States

    12 h-index

    41 publications

    3.9K citations

  3. Duke Medical Center

    Durham, United States

    12 h-index

    42 publications

    3.8K citations

  4. University of Copenhagen

    Copenhagen, Denmark

    11 h-index

    53 publications

    5K citations

  5. Inserm

    Paris, France

    11 h-index

    77 publications

    6K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    11 h-index

    84 publications

    5.7K citations

  7. National Institutes of Health

    Bethesda, United States

    10 h-index

    39 publications

    2.4K citations

  8. Discovery Institute

    Seattle, United States

    9 h-index

    46 publications

    3.9K citations

1–8 of 423

Venues

  1. Journal of Biological Chemistry

    JBC · 14 publications · 1.2K citations

    14

    h-index

  2. Journal of Medicinal Chemistry

    15 publications · 554 citations

    13

    h-index

  3. British Journal of Pharmacology

    BJP · 11 publications · 458 citations

    11

    h-index

  4. Molecular Pharmacology

    10 publications · 798 citations

    10

    h-index

  5. Biochemical Pharmacology

    10 publications · 454 citations

    10

    h-index

1–5