Practical Implementation of Bayesian Dose-Escalation Procedures

Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer

John O’Quigley, Margaret S. Pepe, Lloyd D. Fisher · Biometrics · 1990 · 1.6K citations

Medicine, Biostatistics, Oncology +14

Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition.

D. Ferry, Adam J. de Smith, J Malkhandi et al. · PubMed · 1996 · 630 citations

Medicine, Pharmacokinetics, Pharmacology +12

Cancer phase I clinical trials: efficient dose escalation with overdose control

James S. Babb, André Rogatko, Shelemyahu Zacks · Statistics in Medicine · 1998 · 621 citations

Pharmacy, Biostatistics, Oncology +17

Some practical improvements in the continual reassessment method for phase I studies

Steven N. Goodman, Marianna Zahurak, Steven Piantadosi · Statistics in Medicine · 1995 · 474 citations

Pharmacy, Pharmacology, Dose-response Modeling +11

Continual Reassessment Method: A Likelihood Approach

John O’Quigley, Larry Z. Shen · Biometrics · 1996 · 376 citations

Computing, Biostatistics, Bayesian Biostatistics +9