Concepedia

Model-based Dose Escalation

Model-Based Dose Escalation is a dose-finding methodology in clinical trial design that uses statistical models to guide the escalation of drug dosage by continuously estimating the relationship between dose levels and toxicity outcomes.

92

Publications

4.2K

Citations

376

Authors

187

Institutions

Publications per year

2017–2026

43

Variants

Model-based Dose Finding

Parents

Publications

92

Model‐Informed Drug Development: Current US Regulatory Practice and Future Considerations

Yaning Wang, Hao Zhu, Rajanikanth Madabushi et al. · Clinical Pharmacology & Therapeutics · 2019 · 209 citations

, , +10

A Prospective, Randomized Pilot Trial of Model-Based Warfarin Dose Initiation using CYP2C9 Genotype and Clinical Data

Michael A Hillman, Russell A. Wilke, Steven H. Yale et al. · Clinical Medicine & Research · 2005 · 196 citations · Full text

, , +15

Modified Toxicity Probability Interval Design: A Safer and More Reliable Method Than the 3 + 3 Design for Practical Phase I Trials

Yuan Ji, Sue-Jane Wang · Journal of Clinical Oncology · 2013 · 175 citations

, , +17

Bayesian Model Averaging Continual Reassessment Method in Phase I Clinical Trials

Guosheng Yin, Ying Yuan · Journal of the American Statistical Association · 2009 · 167 citations

, , +16

Time-to-Event Bayesian Optimal Interval Design to Accelerate Phase I Trials

Ying Yuan, Ruitao Lin, Daniel Li et al. · Clinical Cancer Research · 2018 · 128 citations · Full text

, , +15

1–5 of 92

Authors

376

  1. YY
    Ying Yuan

    The University of Texas MD Anderson Cancer Center, United States

    8 publications · 607 citations

    8

    h-index

  2. TJ
    Thomas Jaki

    Lancaster University, United Kingdom

    6 publications · 205 citations

    6

    h-index

  3. YJ
    Yuan Ji

    Endeavor Health, United States

    6 publications · 359 citations

    6

    h-index

  4. AM
    Adrian Mander

    MRC Biostatistics Unit, United Kingdom

    4 publications · 255 citations

    4

    h-index

  5. GY
    Guosheng Yin

    University of Hong Kong, Hong Kong SAR China

    4 publications · 258 citations

    4

    h-index

1–5 of 376

Institutions

187

  1. The University of Texas MD Anderson Cancer Center

    Houston, United States

    14 h-index

    33 publications

    2.1K citations

  2. Lancaster University

    Lancaster, United Kingdom

    8 h-index

    19 publications

    447 citations

  3. MRC Biostatistics Unit

    Cambridge, United Kingdom

    6 h-index

    9 publications

    461 citations

  4. Columbia University

    New York, United States

    5 h-index

    11 publications

    342 citations

  5. University of Chicago

    Chicago, United States

    5 h-index

    6 publications

    251 citations

  6. Center for Drug Evaluation and Research

    Silver Spring, United States

    5 h-index

    11 publications

    1K citations

  7. KU Leuven

    Leuven, Belgium

    5 h-index

    15 publications

    476 citations

  8. Cancer Research UK Clinical Trials Unit

    Birmingham, United Kingdom

    4 h-index

    8 publications

    431 citations

1–8 of 187

Venues

  1. Statistics in Medicine

    11 publications · 499 citations

    11

    h-index

  2. Journal of Biopharmaceutical Statistics

    JBS · 6 publications · 151 citations

    6

    h-index

  3. Pharmaceutical Statistics

    5 publications · 206 citations

    5

    h-index

  4. Clinical Cancer Research

    4 publications · 326 citations

    4

    h-index

  5. BMC Medical Research Methodology

    3 publications · 170 citations

    3

    h-index

1–5