A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

Inge Grundke‐Iqbal, Khurshid Iqbal, Y C Tung et al. · Proceedings of the National Academy of Sciences · 1986 · 3.6K citations · Full text

Life Sciences, Neurobiology, Neuroscience +15

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

K S Kosik, Catharine Joachim, D. J. Selkoe · Proceedings of the National Academy of Sciences · 1986 · 1.5K citations

Life Sciences, Neurobiology, Neuroscience +16

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

Michel Goedert, Claude M. Wischik, R. Anthony Crowther et al. · Proceedings of the National Academy of Sciences · 1988 · 1.1K citations · Full text

Life Sciences, Molecular Biology, Neurobiology +13

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

Claude M. Wischik, M Novák, Hans C. Thøgersen et al. · Proceedings of the National Academy of Sciences · 1988 · 944 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

C. Bancher, Christof Brunner, Hans Lassmann et al. · Brain Research · 1989 · 815 citations

Life Sciences, Molecular Biology, Neuroscience +12