Concepedia

A chemical chaperone, sodium 4-phenylbutyric acid, attenuates the pathogenic potency in human α-synuclein A30P + A53T transgenic mice

Kazuhiko Ono, Miyuki Ikemoto, Takeshi Kawarabayashi, Masaki Ikeda, Takuya Nishinakagawa, Masato Hosokawa, Mikio Shoji, Mitsuo Takahashi, Manabu Nakashima

Parkinsonism & Related Disorders · 2009 · 81 citations · 29 references

DOI

Concepts

References

29

Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes

Umut Özcan, Erkan Yılmaz, Lale Özcan et al. · Science · 2006 · 2.4K citations · Full text

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α-Synuclein is phosphorylated in synucleinopathy lesions

Hideo Fujiwara, Masato Hasegawa, Naoshi Dohmae et al. · Nature Cell Biology · 2002 · 2.2K citations

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Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy

Ana María Cuervo, Leonidas Stefanis, Ross A. Fredenburg et al. · Science · 2004 · 2K citations

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α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

Li Chen, Mel Β. Feany · Nature Neuroscience · 2005 · 614 citations

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Hsp70 Reduces α-Synuclein Aggregation and Toxicity

Jochen Klucken, Youngah Shin, Eliezer Masliah et al. · Journal of Biological Chemistry · 2004 · 509 citations · Full text

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