Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes

Umut Özcan, Erkan Yılmaz, Lale Özcan, +5

Science

Lipid PeroxidationHomeostatic MechanismEr StressMetabolic RemodelingInsulin Signaling +19

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

Lale Özcan, Ayse Seda Ergin, Allen Lu, +5

Cell Metabolism

Central RoleSignal TransductionMolecular PhysiologyDevelopmental BiologyAutophagy +11

Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

Umut Özcan, Lale Özcan, Erkan Yılmaz, +4

Molecular Cell

Signal TransductionSignaling PathwayCell RegulationUnfolded Protein ResponseCell Death +8

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways

Jenelle M. Timmins, Lale Özcan, Tracie A. Seimon, +8

Journal of Clinical Investigation

MitophagyApoptosisImmunologyCell DeathEr Stress +15

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

Gang Li, Christopher M. Scull, Lale Özcan, +1

The Journal of Cell Biology

Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance

Devram Sampat Ghorpade, Lale Özcan, Ze Zheng, +6

Nature

InflammationMetabolic SyndromeObesityInsulin ResistanceInsulin Signaling +12

Calcium Signaling through CaMKII Regulates Hepatic Glucose Production in Fasting and Obesity

Lale Özcan, Catherine C. L. Wong, Gang Li, +12

Cell Metabolism

ObesityMetabolic SyndromeEnergy HomeostasisInsulin SignalingSignal Transduction +11

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B ₄ synthesis by inhibiting a calcium-activated kinase pathway

Gabrielle Fredman, Lale Özcan, Stefano Spolitu, +4

Proceedings of the National Academy of Sciences

Activation of Calcium/Calmodulin-Dependent Protein Kinase II in Obesity Mediates Suppression of Hepatic Insulin Signaling

Lale Özcan, Jane Cristina de Souza, A. Harari, +3

Cell Metabolism

ObesityMetabolic SyndromeEnergy HomeostasisInsulin SignalingMolecular Physiology +13

CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis

Amanda C. Doran, Lale Özcan, Bishuang Cai, +9

Journal of Clinical Investigation

Vascular DiseaseThicker Collagen CapsImmunologyImmune RegulationPathology +17