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Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases

Craig A. Zificsak, Diane E. Gingrich, Henry J. Breslin, Derek Dunn, Karen L. Milkiewicz, Jay Theroff, Tho V. Thieu, Ted L. Underiner, Linda R. Weinberg, Lisa D. Aimone,

Bioorganic & Medicinal Chemistry Letters · 2011 · 19 citations · 7 references

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Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms

Alfonso Quintás‐Cardama, Kris Vaddi, Phillip Liu et al. · Blood · 2010 · 827 citations

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The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

Michael Hedvat, Dennis Huszar, Andreas Herrmann et al. · Cancer Cell · 2009 · 529 citations · Full text

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Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK

Anna Galkin, Jonathan S. Melnick, Sung Joon Kim et al. · Proceedings of the National Academy of Sciences · 2006 · 377 citations · Full text

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Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1

Ha-Soon Choi, Zhicheng Wang, Wendy Richmond et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 66 citations · Full text

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Discovery of a Potent Inhibitor of Anaplastic Lymphoma Kinase with in Vivo Antitumor Activity

Gregory R. Ott, Rabindranath Tripathy, Mangeng Cheng et al. · ACS Medicinal Chemistry Letters · 2010 · 49 citations · Full text

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