Freeze drying formulation using microscale and design of experiment approaches: a case study using granulocyte colony-stimulating factor

Mechanism of protein stabilization by sugars during freeze-drying and storage: Native structure preservation, specific interaction, and/or immobilization in a glassy matrix?

Liuquan Chang, Deanna Shepherd, Joanna Sun et al. · Journal of Pharmaceutical Sciences · 2005 · 451 citations · Full text

Life Sciences, Biochemistry, Food Science +17

Predicting the Stability of Biological Standards and Products

Thomas B. L. Kirkwood · Biometrics · 1977 · 172 citations

Agriculture, Food Science, Food Analysis +15

Aggregation of granulocyte‐colony stimulating factor in vitro involves a conformationally altered monomeric state

Stephen W. Raso, Jeff Abel, Jesse M. Barnes et al. · Protein Science · 2005 · 109 citations · Full text

Life Sciences, Biochemistry, Immunology +17

High‐throughput measurement of protein stability in microtiter plates

Jean P. Aucamp, Ana M. Cosme, Gary J. Lye et al. · Biotechnology and Bioengineering · 2005 · 62 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Design and analysis of accelerated degradation tests for the stability of biological standards II. A flexible computer program for data analysis

Thomas B. L. Kirkwood, M.S. Tydeman · Journal of Biological Standardization · 1984 · 59 citations

Engineering, Bioengineering, Biological Engineering +13