Anandamide and 2-Arachidonoylglycerol Inhibit Fatty Acid Amide Hydrolase by Activating the Lipoxygenase Pathway of the Arachidonate Cascade

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

William A. Devane, Aviva Breuer, Roger G. Pertwee et al. · Science · 1992 · 5.6K citations

Life Sciences, Neuroscience, Pharmacology +15

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

Benjamin F. Cravatt, Dan K. Giang, Stephen P. Mayfield et al. · Nature · 1996 · 2.1K citations

Life Sciences, Biochemistry, Neuroscience +14

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

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Life Sciences, Immunology, Pharmacology +17

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

Ravi G. Kurumbail, Anna M. Stevens, James K. Gierse et al. · Nature · 1996 · 1.9K citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Control of pain initiation by endogenous cannabinoids

Antonio Calignano, Giovanna La Rana, Andrea Giuffrida et al. · Nature · 1998 · 1.1K citations

Medicine, Neurobiology, Pharmacology +14