Concepedia

Development of dimeric modulators for anti-apoptotic Bcl-2 proteins

Liangyou Wang, Candis Kokoski, David W. Andrews, Chengguo Xing

Bioorganic & Medicinal Chemistry Letters · 2007 · 31 citations · 19 references

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19

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Tilman Oltersdorf, Steven W. Elmore, Alexander R. Shoemaker et al. · Nature · 2005 · 3.4K citations

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Structure of Bcl-x <sub>L</sub> -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

Michael Sattler, Heng Liang, David G. Nettesheim et al. · Science · 1997 · 1.5K citations

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Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

Christian Frezza, Sara Cipolat, Luca Scorrano · Nature Protocols · 2007 · 1.2K citations

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Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

Jialun Wang, Dongxiang Liu, Zhijia Zhang et al. · Proceedings of the National Academy of Sciences · 2000 · 1.2K citations

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Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity

Tim Clackson, Yang Wu, Leonard W. Rozamus et al. · Proceedings of the National Academy of Sciences · 1998 · 564 citations

, , +17