Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity

Tim Clackson, Yang Wu, Leonard W. Rozamus, +11

Proceedings of the National Academy of Sciences

Fkbp–ligand InterfaceProtein AssemblyMolecular BiologyChemistryMolecular Design +17

A Repressor Complex Governs the Integration of Flowering Signals in Arabidopsis

Dan Li, Chang Liu, Lisha Shen, +7

Developmental Cell

BiologyPlant BiologyPattern FormationPlant Molecular BiologyHealth Sciences +8

Drug repurposing from an academic perspective

Tudor I. Oprea, Julie E. Bauman, Cristian Bologa, +26

Drug Discovery Today Therapeutic Strategies

Academic PerspectiveSubstance AbuseDrug RepositioningAddictionPrescription Drugs +7

Control of Molecular Transport Through Stimuli‐Responsive Ordered Mesoporous Materials

Qiang Fu, G. V. Rama Rao, Linnea K. Ista, +5

Advanced Materials

Chemical EngineeringMesoporous ArchitecturesEngineeringNanoporous MaterialPorous Carbon +11

Neuronal Control of <i>Drosophila</i> Walking Direction

Salil S. Bidaye, Christian Machacek, Yang Wu, +1

Science

Sensorimotor ControlBipedal LocomotionNeural MechanismKinesiologyMdn Neurons +13

A versatile synthetic dimerizer for the regulation of protein–protein interactions

Jane F. Amara, Tim Clackson, Victor M. Rivera, +8

Proceedings of the National Academy of Sciences

Drug TargetProtein AssemblyChemical ModificationMolecular BiologyInduced Dimerization +16

Investigating Protein−Ligand Interactions with a Mutant FKBP Possessing a Designed Specificity Pocket

Yang Wu, Leonard W. Rozamus, Surinder S. Narula, +9

Journal of Medicinal Chemistry

Protein AssemblyHydrophobic Specificity PocketBiomolecular Structure PredictionNovel Synthetic LigandsMolecular Biology +17

Identification of a Small GTPase Inhibitor Using a High-Throughput Flow Cytometry Bead-Based Multiplex Assay

Zurab Surviladze, Anna Waller, Yang Wu, +4

SLAS DISCOVERY

Fabrication of Fe3O4/Au@ATP@Ag Nanorod sandwich structure for sensitive SERS quantitative detection of histamine

Ting Zhou, Min Fan, Ruiyun You, +7

Analytica Chimica Acta

NanomedicineEngineeringBiosensing SystemsBiochemistryBiomedical Diagnostics +7

Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins

Terence P. Keenan, David Yaeger, Nancy L. Courage, +9

Bioorganic & Medicinal Chemistry

Protein ChemistryProtein FunctionBiochemistryProtein AssemblyProtein Folding +6