Concepedia

Bcl-2 Protein Dimerization

Bcl-2 Protein Dimerization is a biochemical interaction process in which two Bcl-2 family proteins form a heterodimeric or homodimeric complex through their hydrophobic grooves and BH domains, thereby regulating mitochondrial outer membrane permeabilization and apoptotic cell death.

85

Publications

19.9K

Citations

389

Authors

133

Institutions

Publications per year

2017–2026

3

Parents

Publications

85

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

Zoltán N. Oltval, Curt Milliman, Stanley J. Korsmeyer · Cell · 1993 · 6K citations

, , +12

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

Elizabeth Yang, Jiping Zha, Jennifer Jockel et al. · Cell · 1995 · 2.1K citations · Full text

, , +7

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

Xiao-Ming Yin, Zoltán N. Oltvai, Stanley J. Korsmeyer · Nature · 1994 · 1.3K citations

, , +5

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

Thomas W. Sedlak, Zoltán N. Oltvai, Elizabeth Yang et al. · Proceedings of the National Academy of Sciences · 1995 · 821 citations

, , +17

Nonionic Detergents Induce Dimerization among Members of the Bcl-2 Family

Yi‐Te Hsu, Richard J. Youle · Journal of Biological Chemistry · 1997 · 592 citations · Full text

, , +15

1–5 of 85

Authors

389

  1. JC
    John C. Reed

    Sanford Burnham Prebys Medical Discovery Institute, United States

    10 publications · 2.4K citations

    10

    h-index

  2. SJ
    Stanley J. Korsmeyer

    Howard Hughes Medical Institute, United States

    5 publications · 9.7K citations

    5

    h-index

  3. TS
    Takaaki Sato

    Kyoto University, Japan

    5 publications · 1.9K citations

    5

    h-index

  4. CB
    Craig B. Thompson

    University of Pennsylvania, United States

    5 publications · 3.8K citations

    5

    h-index

  5. HW
    Hong‐Gang Wang

    Penn State Milton S. Hershey Medical Center, United States

    4 publications · 1.1K citations

    4

    h-index

1–5 of 389

Institutions

133

  1. Sanford Burnham Prebys Medical Discovery Institute

    La Jolla, United States

    10 h-index

    45 publications

    11.2K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    8 h-index

    26 publications

    35.6K citations

  3. National Foundation for Cancer Research

    Bethesda, United States

    6 h-index

    39 publications

    13.4K citations

  4. Stanford University

    Stanford, United States

    5 h-index

    10 publications

    1.6K citations

  5. Molecular Oncology (United States)

    Gaithersburg, United States

    4 h-index

    12 publications

    4.8K citations

  6. Washington University in St. Louis

    St Louis, United States

    3 h-index

    8 publications

    12.7K citations

  7. Abbott (United States)

    Chicago, United States

    3 h-index

    7 publications

    702 citations

  8. McMaster University

    Hamilton, Canada

    3 h-index

    7 publications

    419 citations

1–8 of 133

Venues

  1. Journal of Biological Chemistry

    JBC · 19 publications · 3.7K citations

    19

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 1.9K citations

    4

    h-index

  3. Molecular and Cellular Biology

    MCB · 4 publications · 653 citations

    4

    h-index

  4. Biochemical Journal

    BJ · 3 publications · 107 citations

    3

    h-index

  5. Cell Death and Differentiation

    CDD · 2 publications · 285 citations

    2

    h-index

1–5