Diazinon Is Activated by CYP2C19 in Human Liver

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Medicine, Biochemistry, Pharmacology +15

Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.

Deborah J. Newton, R W Wang, Anthony Y.H. Lu · Drug Metabolism and Disposition · 1995 · 606 citations

Medicine, Pharmacokinetics, Pharmacology +17

Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

Thomas Kronbach, Daniel Mathys, Makoto Umeno et al. · Molecular Pharmacology · 1989 · 535 citations

Medicine, Pharmacology, Biochemical Pharmacology +15

Evaluation of the selectivity of In vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities.

Dean Hickman, Ji Ping Wang, Yi Wang et al. · PubMed · 1998 · 223 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms.

Jae Wook Ko, Nadia Sukhova, David Thacker et al. · PubMed · 1997 · 210 citations

Medicine, Pharmacokinetics, Pharmacology +17