Evaluation of the selectivity of In vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities.

Dean Hickman, Ji Ping Wang, Yi Wang, +1

PubMed

EngineeringPharmacotherapyMedicinal ChemistryOrganic SolventsPharmacological Study +18

Discovery of<i>N</i>-(4-(3-Amino-1<i>H</i>-indazol-4-yl)phenyl)-<i>N</i>‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitor

Yujia Dai, Kresna Hartandi, Zhiqin Ji, +25

Journal of Medicinal Chemistry

Compound 17PDrug TargetChemoprevention StrategyKinase InhibitorsPharmacotherapy +18

N-acetyltransferase polymorphism

Dean Hickman, Edith Sim

Biochemical Pharmacology

Potent Inhibition of the Cytochrome P-450 3A-Mediated Human Liver Microsomal Metabolism of a Novel HIV Protease Inhibitor by Ritonavir: A Positive Drug-Drug Interaction

Gondi Kumar, J.C. Dykstra, Ellen Roberts, +7

Drug Metabolism and Disposition

Expression of arylamine <i>N</i> -acetyltransferase in human intestine

Dean Hickman, J. Pope, Shivakumar D. Patil, +6

Gut

From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1)

Yuan Cheng, Ted Judd, Michael D. Bartberger, +19

Journal of Medicinal Chemistry

An on-chip model of protein paracellular and transcellular permeability in the microcirculation

Giovanni S. Offeddu, Kristina Haase, Mark R. Gillrie, +5

Biomaterials

EngineeringMedicineMembrane TransportProtein ParacellularBiofluid Dynamic +11

Chromosomal localization of human genes for arylamine <i>N</i>-acetyltransferase

Dean Hickman, Angela Risch, V J Buckle, +4

Biochemical Journal

ChromatinHuman Chromosome 8Arylamine N-acetyltransferaseCytogeneticsBenzidine-induced Bladder Cancer +12

Genotyping human polymorphic arylamine N-acetyltransferase: identification of new slow allotypic variants

Dean Hickman, Angela Risch, J. Camilleri, +1

Pharmacogenetics

Arylamine N-acetyltransferase in human red blood cells

Alison Ward, Dean Hickman, Jonathan W. Gordon, +1

Biochemical Pharmacology

Arylamine N-acetyltransferaseBiochemistryReactive Nitrogen SpecieMedicineBlood Cell +5