Dean Hickman

Evaluation of the selectivity of In vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities.

Dean Hickman, Ji Ping Wang, Yi Wang et al. · PubMed · 1998 · 223 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Discovery of<i>N</i>-(4-(3-Amino-1<i>H</i>-indazol-4-yl)phenyl)-<i>N</i>‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitor

Yujia Dai, Kresna Hartandi, Zhiqin Ji et al. · Journal of Medicinal Chemistry · 2007 · 185 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

N-acetyltransferase polymorphism

Dean Hickman, Edith Sim · Biochemical Pharmacology · 1991 · 171 citations

Potent Inhibition of the Cytochrome P-450 3A-Mediated Human Liver Microsomal Metabolism of a Novel HIV Protease Inhibitor by Ritonavir: A Positive Drug-Drug Interaction

Gondi Kumar, J.C. Dykstra, Ellen Roberts et al. · Drug Metabolism and Disposition · 1999 · 166 citations

Medicine, Pharmacokinetics, Pharmacology +17

From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1)

Yuan Cheng, Ted Judd, Michael D. Bartberger et al. · Journal of Medicinal Chemistry · 2011 · 141 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17