Gene optimization is necessary to express a bivalent anti-human anti-T cell immunotoxin in Pichia pastoris

One molecule of diphtheria toxin fragment a introduced into a cell can kill the cell

Masaru Yamaizumi, Eisuke Mekada, Tsuyoshi Uchida et al. · Cell · 1978 · 752 citations

Signal Transduction, Toxinology, Natural Sciences +12

Diphtheria toxin entry into cells is facilitated by low pH.

Kirsten Sandvig, Sjur Olsnes · The Journal of Cell Biology · 1980 · 467 citations · Full text

Microbial Toxin, Diphtheria Toxin Entry, Biochemistry +15

The entry of diphtheria toxin into the mammalian cell cytoplasm: evidence for lysosomal involvement.

Rockford K. Draper, M I Simon · The Journal of Cell Biology · 1980 · 373 citations · Full text

Mammalian Cell Cytoplasm, Protein Secretion, Toxinology +21

High–Level Expression and Efficient Assembly of Hepatitis B Surface Antigen in the Methylotrophic Yeast, Pichia Pastoris

J M Cregg, J Tschopp, Cathy A. Stillman et al. · Nature Biotechnology · 1987 · 336 citations

Engineering, Natural Sciences, Biochemical Engineering +9

Protein L from Peptostreptococcus magnus binds to the kappa light chain variable domain.

Bo Nilson, Alan Solomon, Lars Björck et al. · Journal of Biological Chemistry · 1992 · 220 citations · Full text

Protein Chemistry, Protein Function, Protein L +15