One molecule of diphtheria toxin fragment a introduced into a cell can kill the cell

Masaru Yamaizumi, Eisuke Mekada, Tsuyoshi Uchida, +1

Cell

Signal TransductionToxinologyNatural SciencesCell InteractionPathogenesis +10

Requirement of CD9 on the Egg Plasma Membrane for Fertilization

Kenji Miyado, Gen Yamada, Shuichi Yamada, +9

Science

OocyteSperm-egg FusionFertilityGeneticsEgg Plasma Membrane +14

Diphtheria toxin receptor–mediated conditional and targeted cell ablation in transgenic mice

Michiko Saito, Takao Iwawaki, Choji Taya, +7

Nature Biotechnology

Knockout MouseSignal TransductionCell AblationDiphtheria ToxinImmunology +6

Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

Ryo Iwamoto, Satoru Yamazaki, Masanori Asakura, +12

Proceedings of the National Academy of Sciences

Diphtheria Toxin Binds to the Epidermal Growth Factor (EGF)-like Domain of Human Heparin-binding EGF-like Growth Factor/Diphtheria Toxin Receptor and Inhibits Specifically Its Mitogenic Activity

T. Mitamura, Shigeki Higashiyama, Naoyuki Taniguchi, +2

Journal of Biological Chemistry

Dt BindingEpidermal Growth FactorSignal TransductionMolecular PhysiologyMitogenic Activity +13

Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing

Yuji Shirakata, Rina Kimura, Daisuke Nanba, +8

Journal of Cell Science

Skin DevelopmentCutaneous BiologyKeratinocyte MigrationSkin Wound HealingPredominant Growth Factor +10

The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor.

Shigeki Higashiyama, Ryo Iwamoto, K. Goishi, +4

The Journal of Cell Biology

Toxin ReceptorSignal TransductionMolecular PhysiologyTumor MicroenvironmentMitogenic Activity +12

Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity.

K. Goishi, Shigeki Higashiyama, Michael Klagsbrun, +5

Molecular Biology of the Cell

Signal TransductionGrowth Factor ActivityGrowth HormoneMedicineCell Adhesion +13

Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity.

Ryo Iwamoto, Shigeki Higashiyama, T. Mitamura, +3

The EMBO Journal

Protein FunctionSignal TransductionSignaling PathwayReceptor Tyrosine KinaseDiphtheria Toxin Sensitivity +7

Membrane-anchored heparin-binding EGF-like growth factor (HB-EGF) and diphtheria toxin receptor-associated protein (DRAP27)/CD9 form a complex with integrin alpha 3 beta 1 at cell-cell contact sites.

Kuniaki Nakamura, Ryo Iwamoto, Eisuke Mekada

The Journal of Cell Biology

Mitogenic ActivityCell AdhesionImmunologyCell GrowthCellular Physiology +16