Analytical Chemistry · 2002 · 70 citations · 18 references
EngineeringChemical EngineeringMechanical EngineeringFluid DynamicsFluid MechanicsNanotechnologyBubble DynamicsMicrofluidic DevicesMicrofluidic SystemsMicrofluidicsMicromachiningSurface MicromachiningBubble Dynamics In MicrochannelsLiquid FlowMicrochannel FlowMicrochannel HydrodynamicsMicrofluidic Device DesignMicrofluidic FlowMicrofluidic PumpsSurface Micromachined Actuators
A new concept for liquid manipulation has been developed and implemented in surface-micromachined fluid channels. It is based on the surface tension directed injection of a gas into the liquid flow through micrometer-sized holes in the microchannel wall. The injected gas is directed to an exhaust by a cross-sectional asymmetry of the microchannel and thereby moves minute liquid volumes. Successful pumping experiments were performed with single stroke volumes of tens of picoliters at frequencies around 1 Hz. The minimum actuation pressure is 0.6 bar for a 2-microm channel height, in accordance with theoretical predictions.
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An Integrated Nanoliter DNA Analysis Device
Mark A. Burns, Brian N. Johnson, Sundaresh N. Brahmasandra et al. · Science · 1998 · 1.3K citations