Concepedia

17-AAG Kills Intracellular Leishmania amazonensis while Reducing Inflammatory Responses in Infected Macrophages

Antônio Luis de Oliveira Almeida Petersen, Carlos Eduardo Sampaio Guedes, Carolina Leite Versoza, José Geraldo Bomfim Lima, Luiz Antônio Rodrigues de Freitas, Valéria M. Borges, Patrícia Sampaio Tavares Veras

PLoS ONE · 2012 · 45 citations · 36 references

DOIFull text

Open access

Abstract

The HSP90 inhibitor, 17-AAG, possesses high potency under low dosage and reduces both pro-inflammatory and oxidative molecule production. Therefore, further studies are warranted to investigate this inhibitor's potential in the development of new generations of anti-leishmanials.

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