Inhibition of Shc/Grb2 protein–protein interaction suppresses growth of B104-1-1 tumors xenografted in nude mice

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

Giuliana Pelicci, Luisa Lanfrancone, F Grignani et al. · Cell · 1992 · 1.3K citations

Life Sciences, Biochemistry, Molecular Biology +14

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

Maria Rozakis-Adcock, Jane McGlade, Geraldine Mbamalu et al. · Nature · 1992 · 993 citations

Life Sciences, Biochemistry, Molecular Biology +15

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

Judith S. Sebolt–Leopold, David T. Dudley, Román Herrera et al. · Nature Medicine · 1999 · 969 citations

Medicine, Cancer Biology, Oncology +14

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

Zhou Songyang, Steven E. Shoelson, Jane McGlade et al. · Molecular and Cellular Biology · 1994 · 878 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway

Ami Aronheim, David Engelberg, Nanxin Li et al. · Cell · 1994 · 459 citations

Life Sciences, Cell Biology, Molecular Biology +12