Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

Christian Thiede, Christine Steudel, Brigitte Mohr et al. · Blood · 2002 · 1.7K citations · Full text

Medicine, Genetics, Hematology +14

Guidelines for the welfare and use of animals in cancer research

Paul Workman, Eric O. Aboagye, Frances R. Balkwill et al. · British Journal of Cancer · 2010 · 1.4K citations · Full text

Medicine, Animal Sciences, Oncology +17

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

Patrick P. Zarrinkar, Ruwanthi N. Gunawardane, Merryl Cramer et al. · Blood · 2009 · 644 citations · Full text

Medicine, Medicinal Chemistry, Oncology +14

Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study.

Susan P. Whitman, Kellie J. Archer, Claudia D. Baldus et al. · PubMed · 2001 · 638 citations

Life Sciences, Genetics, Molecular Genetics +14

Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways

Masao Mizuki, R. Fenski, Hartmut Halfter et al. · Blood · 2000 · 581 citations

Medicine, Genetics, Molecular Biology +9