Sian Avery

Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns

Andrew S. Moore, Amir Faisal, David González de Castro et al. · Leukemia · 2012 · 119 citations · Full text

Medicine, Genetics, Oncology +14

The Aurora Kinase Inhibitor CCT137690 Downregulates MYCN and Sensitizes <i>MYCN</i> -Amplified Neuroblastoma <i>In Vivo</i>

Amir Faisal, Lynsey Vaughan, Vassilios Bavetsias et al. · Molecular Cancer Therapeutics · 2011 · 85 citations · Full text

Medicine, Oncology, Pharmacology +17

Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-<i>b</i>]pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells

Vassilios Bavetsias, Amir Faisal, Simon Crumpler et al. · Journal of Medicinal Chemistry · 2013 · 78 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Optimization of Imidazo[4,5-<i>b</i>]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia

Vassilios Bavetsias, Simon Crumpler, Chongbo Sun et al. · Journal of Medicinal Chemistry · 2012 · 72 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent

Vassilios Bavetsias, Yolanda Pérez-Fuertes, Patrick J. McIntyre et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 16 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17