Simon Crumpler

Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19

Aurélie Mallinger, Kai Schiemann, Christian Rink et al. · Journal of Medicinal Chemistry · 2016 · 112 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen

Aurélie Mallinger, Simon Crumpler, Mark Pichowicz et al. · Journal of Medicinal Chemistry · 2015 · 80 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +14

Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-<i>b</i>]pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells

Vassilios Bavetsias, Amir Faisal, Simon Crumpler et al. · Journal of Medicinal Chemistry · 2013 · 78 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Optimization of Imidazo[4,5-<i>b</i>]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia

Vassilios Bavetsias, Simon Crumpler, Chongbo Sun et al. · Journal of Medicinal Chemistry · 2012 · 72 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Palladium catalysed synthesis of cyclic amidines and imidates

C. Gustaf Saluste, Simon Crumpler, Mark Furber et al. · Tetrahedron Letters · 2004 · 71 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10