Lynsey Vaughan

The Aurora Kinase Inhibitor CCT137690 Downregulates MYCN and Sensitizes <i>MYCN</i> -Amplified Neuroblastoma <i>In Vivo</i>

Amir Faisal, Lynsey Vaughan, Vassilios Bavetsias et al. · Molecular Cancer Therapeutics · 2011 · 82 citations · Full text

<i> <scp>HUWE</scp> 1 </i> is a critical colonic tumour suppressor gene that prevents <scp>MYC</scp> signalling, <scp>DNA</scp> damage accumulation and tumour initiation

Kevin Myant, Patrizia Cammareri, Michael C. Hodder et al. · EMBO Molecular Medicine · 2016 · 72 citations · Full text

HUWE1 Ubiquitylates and Degrades the RAC Activator TIAM1 Promoting Cell-Cell Adhesion Disassembly, Migration, and Invasion

Lynsey Vaughan, Chong Teik Tan, Anna Chapman et al. · Cell Reports · 2014 · 61 citations · Full text

Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors

Lynsey Vaughan, Paul A. Clarke, Karen Barker et al. · Oncotarget · 2016 · 53 citations · Full text

Evaluation of Clinically Translatable MR Imaging Biomarkers of Therapeutic Response in the TH-<i>MYCN</i>Transgenic Mouse Model of Neuroblastoma

Yann Jamin, Elizabeth R. Tucker, Evon Poon et al. · Radiology · 2012 · 35 citations · Full text