Lynsey Vaughan

The Aurora Kinase Inhibitor CCT137690 Downregulates MYCN and Sensitizes <i>MYCN</i> -Amplified Neuroblastoma <i>In Vivo</i>

Amir Faisal, Lynsey Vaughan, Vassilios Bavetsias et al. · Molecular Cancer Therapeutics · 2011 · 85 citations · Full text

Medicine, Oncology, Pharmacology +17

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

Kevin Myant, Patrizia Cammareri, Michael C. Hodder et al. · EMBO Molecular Medicine · 2016 · 73 citations · Full text

Medicine, Genetics, Oncology +17

HUWE1 Ubiquitylates and Degrades the RAC Activator TIAM1 Promoting Cell-Cell Adhesion Disassembly, Migration, and Invasion

Lynsey Vaughan, Chong Teik Tan, Anna Chapman et al. · Cell Reports · 2014 · 62 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors

Lynsey Vaughan, Paul A. Clarke, Karen Barker et al. · Oncotarget · 2016 · 59 citations · Full text

Medicine, Oncology, Pharmacology +17

miRNA Expression Profiling of the Murine TH-MYCN Neuroblastoma Model Reveals Similarities with Human Tumors and Identifies Novel Candidate MiRNAs

Marta Terrile, Kenneth Bryan, Lynsey Vaughan et al. · PLoS ONE · 2011 · 35 citations · Full text

Medicine, Cancer Biology, Oncology +17