Paul A. Clarke

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

Georgios Vlachogiannis, Somaieh Hedayat, Alexandra Vatsiou et al. · Science · 2018 · 1.9K citations · Full text

Kirsten ras Mutations in Patients With Colorectal Cancer: the Multicenter "RASCAL" Study

Jervoise Andreyev, Alyson Norman, Paul A. Clarke et al. · JNCI Journal of the National Cancer Institute · 1998 · 740 citations · Full text

The Identification of 2-(1<i>H</i>-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-<i>d</i>]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

Adrian Folkes, Khatereh Ahmadi, W. Alderton et al. · Journal of Medicinal Chemistry · 2008 · 739 citations · Full text

Pi3 Kinase, Chemoprevention Strategy, Pharmacotherapy +18

Activation of the ATPase Activity of Hsp90 by the Stress-Regulated Cochaperone Aha1

Barry Panaretou, Giuliano Siligardi, Philippe Meyer et al. · Molecular Cell · 2002 · 541 citations · Full text

Atpase Activity, Reductive Stress, Signal Transduction +10

BCL-2 antisense therapy in patients with non-Hodgkin lymphoma

Andrew Webb, David Cunningham, Finbarr E. Cotter et al. · The Lancet · 1997 · 498 citations

Bcl-2 Antisense Therapy, Lymphoid Neoplasia, Medicine +4