Adding an unnatural covalent bond to proteins through proximity-enhanced bioreactivity

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

Bryson D. Bennett, Elizabeth Kimball, Melissa Gao et al. · Nature Chemical Biology · 2009 · 1.9K citations · Full text

Life Sciences, Biochemistry, Microbiology +16

Far-red fluorescent tags for protein imaging in living tissues

Dmitry Shcherbo, Christopher S. Murphy, Galina V. Ermakova et al. · Biochemical Journal · 2009 · 590 citations · Full text

Natural Sciences, Biochemistry, Molecular Biology +16

Structural Bioinformatics-Based Design of Selective, Irreversible Kinase Inhibitors

Michael S. Cohen, Chao Zhang, Kevan M. Shokat et al. · Science · 2005 · 508 citations · Full text

Life Sciences, Bioinformatics, Medicinal Chemistry +15

Evolution of new nonantibody proteins via iterative somatic hypermutation

Lei Wang, W. Coyt Jackson, Paul Steinbach et al. · Proceedings of the National Academy of Sciences · 2004 · 415 citations · Full text

Life Sciences, Immunology, Molecular Biology +15

Addition of the keto functional group to the genetic code of <i>Escherichia</i> <i>coli</i>

Lei Wang, Zhiwen Zhang, Ansgar Brock et al. · Proceedings of the National Academy of Sciences · 2002 · 352 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15