Concepedia

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells

Yili Yang, Robert L. Ludwig, Jane P. Jensen, Shervon A. Pierre, Maxine V. Medaglia, Ilia V. Davydov, Yassamin J. Safiran, Pankaj Oberoi, John H. Kenten, Andrew C. Phillips,

Cancer Cell · 2005 · 319 citations · 54 references

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54

Surfing the p53 network

Bert Vogelstein, David P. Lane, Arnold J. Levine · Nature · 2000 · 6.6K citations

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In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations

, , +15

Regulation of p53 stability by Mdm2

Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden · Nature · 1997 · 3.3K citations

, , +10

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

Scott W. Lowe, H. Earl Ruley, Tyler Jacks et al. · Cell · 1993 · 2.9K citations

, , +14

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

Martin Scheffner, Jon M. Huibregtse, Richard D. Vierstra et al. · Cell · 1993 · 2.4K citations

, , +15