Fasting Induces Nuclear Factor E2-Related Factor 2 and ATP-Binding Cassette Transporters <i>via</i> Protein Kinase A and Sirtuin-1 in Mouse and Human

Abstract

The current data point toward a novel role of nutrient status in regulation of NRF2 activity and the antioxidant response, and indicates that cAMP/PKA and SIRT1 are upstream regulators for fasting-induced activation of the NRF2-ARE pathway.