Programmed Cell Senescence during Mammalian Embryonic Development

Daniel Muñoz‐Espín, Marta Cañamero, Antonio Maraver, +8

Cell

Developmental BiologyProgrammed Cell SenescenceMorphogenesisCellular SenescenceCell Fate Determination +4

Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice

Carmen Guerra, Alberto J. Schuhmacher, Marta Cañamero, +6

Cancer Cell

Chronic PancreatitisPancreatic CancerOncogenic AgentPancreatic Fluid CollectionGastroenterology +8

The Ink4/Arf locus is a barrier for iPS cell reprogramming

Han Li, Manuel Collado, Aránzazu Villasante, +5

Nature

Signal TransductionMolecular ResearchGeneticsGenomic MechanismInk4/arf Locus +4

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

Daniel Herranz, Maribel Muñoz‐Martín, Marta Cañamero, +4

Nature Communications

Metabolic SyndromeOncologyHealthy AgeingMedicinePathology +6

Reprogramming in vivo produces teratomas and iPS cells with totipotency features

María Abad, Lluc Mosteiro, Cristina Pantoja, +10

Nature

Totipotency FeaturesInduced Pluripotent Stem CellDevelopmental BiologyCell ReprogrammingVivo Produces Teratomas +5

Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence

Carmen Guerra, Manuel Collado, Carolina Navas, +6

Cancer Cell

InflammationPancreatic CancerImmunologyPathologyCell Death +6

Genomic stability and tumour suppression by the APC/C cofactor Cdh1

Irene García-Higuera, Eusebio Manchado, Pierre Dubus, +4

Nature Cell Biology

Tumor BiologyOncogenic AgentCancer GenomicsApc/c Cofactor Cdh1Tumor Suppressor +5

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

Matilde Murga, Samuel F. Bunting, Maria F Montaña, +6

Nature Genetics

Knockout MouseDevelopmental BiologyAgingCell DivisionMorphogenesis +9

Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity

Ana Ortega-Molina, Alejo Efeyan, Elena Lopez-Guadamillas, +12

Cell Metabolism

ObesityMetabolic SyndromeEnergy HomeostasisEnergy MetabolismAging +9

c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma

Rafael B. Blasco, Sarah Francoz, David Santamarı́a, +5

Cancer Cell

Oncogenic AgentMedicinePathologyBronchial NeoplasmCancer Biology +5