Simple non-ion-paired high-performance liquid chromatographic method for simultaneous quantitation of carboxylate and lactone forms of 14 new camptothecin derivatives

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.3K citations · Full text

Chromatin, Genome Instability, Dna Damage +12

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

Monroe E. Wall, Mansukh C. Wani, Clarence Cook et al. · Journal of the American Chemical Society · 1966 · 2.2K citations

Chemoprevention Strategy, Novel Alkaloidal Leukemia, Altmetric Attention Score +21

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

Yasuyoshi Kawato, Masashi Aonuma, Yasuhide Hirota et al. · PubMed · 1991 · 874 citations

Medicinal Chemistry, Chemoprevention Strategy, Camptothecin Derivative Cpt-11 +12

Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA

Matthew R. Redinbo, Lance Stewart, Peter Kühn et al. · Science · 1998 · 874 citations

A Model for the Mechanism of Human Topoisomerase I

Lance Stewart, Matthew R. Redinbo, Xiayang Qiu et al. · Science · 1998 · 698 citations