Concepedia

Structure-activity relationships of carbocyclic influenza neuraminidase inhibitors

Matthew A. Williams, Willard Lew, Dirk B. Mendel, Chun Y. Tai, Paul A. Escarpe, W.G. Laver, Raymond C. Stevens, Choung U. Kim

Bioorganic & Medicinal Chemistry Letters · 1997 · 52 citations · 17 references

DOI

Concepts

References

17

Rational design of potent sialidase-based inhibitors of influenza virus replication

Mark von Itzstein, Wen‐Yang Wu, Gaik B. Kok et al. · Nature · 1993 · 1.9K citations

, , +16

Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site:  Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Anti-Influenza Activity

Choung U. Kim, Willard Lew, Matthew A. Williams et al. · Journal of the American Chemical Society · 1997 · 1.1K citations

, , +17

Influenza type A virus neuraminidase does not play a role in viral entry, replication, assembly, or budding

C Liu, Maryna C. Eichelberger, Richard W. Compans et al. · Journal of Virology · 1995 · 372 citations · Full text

, , +16

4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro

Jacqueline M. Woods, Richard C. Bethell, Jonathon Alexis Coates et al. · Antimicrobial Agents and Chemotherapy · 1993 · 312 citations

, , +12

Safety and Efficacy of the Neuraminidase Inhibitor GG167 in Experimental Human Influenza

Frederick G. Hayden · JAMA · 1996 · 281 citations

, , +14