Constitutive activation of the shh–ptc1 pathway by a patched1 mutation identified in BCC

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

Heidi Hahn, Carol Wicking, Peter G. Zaphiropoulos et al. · Cell · 1996 · 2K citations · Full text

Medicine, Genetics, Molecular Genetics +16

Human Homolog of <b> <i>patched</i> </b> , a Candidate Gene for the Basal Cell Nevus Syndrome

Ronald L. Johnson, Alana Rothman, Jingwu Xie et al. · Science · 1996 · 1.9K citations

Life Sciences, Genetics, Oncology +17

Activating Smoothened mutations in sporadic basal-cell carcinoma

Jingwu Xie, Maximilien Murone, Shiuh-Ming Luoh et al. · Nature · 1998 · 1.3K citations

Veterinary Medicine, Genetics, Oncology +10

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Jussi Taipale, James Chen, Michael K. Cooper et al. · Nature · 2000 · 1.3K citations

Medicine, Cancer Biology, Oncology +9

Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

Erich Roessler, Elena Belloni, Karin Gaudenz et al. · Nature Genetics · 1996 · 1.2K citations

Life Sciences, Genetics, Molecular Genetics +6