Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: Synthesis, biological evaluation and structure–activity relationships. Part 2

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts

David W. Fry, Patricia J. Harvey, Paul R. Keller et al. · Molecular Cancer Therapeutics · 2004 · 1.2K citations

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Inhibition of Cyclin‐Dependent Kinases by Purine Analogues

Jaroslav Veselý, Libor Havlı́ček, Miroslav Strnad et al. · European Journal of Biochemistry · 1994 · 626 citations · Full text

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Structural basis of cyclin-dependent kinase activation by phosphorylation

Alicia A. Russo, Philip D. Jeffrey, Nikola P. Pavletich · Nature Structural & Molecular Biology · 1996 · 594 citations

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Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells.

Bradley A. Carlson, M M Dubay, Edward A. Sausville et al. · PubMed · 1996 · 537 citations

Medicine, Oncology, Pharmacology +14

Discovery of a Potent and Selective Inhibitor of Cyclin-Dependent Kinase 4/6

Peter L. Toogood, Patricia J. Harvey, Joseph T. Repine et al. · Journal of Medicinal Chemistry · 2005 · 503 citations · Full text

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