Takao Horiuchi

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

Hiroaki Hemmi, Tsuneyasu Kaisho, Osamu Takeuchi et al. · Nature Immunology · 2002 · 2.5K citations

Life Sciences, Immunology, Pharmacology +16

Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins

Osamu Takeuchi, Shintaro Sato, Takao Horiuchi et al. · The Journal of Immunology · 2002 · 1.3K citations · Full text

Life Sciences, Immunology, Microbiology +17

Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor

Daisuke Honma, Osamu Kanno, Jun Watanabe et al. · Cancer Science · 2017 · 139 citations · Full text

Medicine, Molecular Biology, Oncology +17

Construction of a plasmid vector for the regulatable high level expression of eukaryotic genes in <i>Escherichia coli</i>: an application to overproduction of chicken lysozyme

Takeyoshi Miki, Takanori Yasukochi, Hiroko Nagatani et al. · Protein Engineering Design and Selection · 1987 · 107 citations

Life Sciences, Biotechnology, Genetics +17

Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: Synthesis, biological evaluation, and structure–activity relationships

Takao Horiuchi, Jun Chiba, Kouichi Uoto et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 99 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16