Concepedia

The intracellular domain of Jagged-1 interacts with Notch1 intracellular domain and promotes its degradation through Fbw7 E3 ligase

Mi‐Yeon Kim, Jane Jung, Jung‐Soon Mo, Eun‐Jung Ann, Ji‐Seon Ahn, Ji‐Hye Yoon, Hee-Sae Park

Experimental Cell Research · 2011 · 37 citations · 41 references

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41

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

Bart De Strooper, Wim Annaert, Philippe Cupers et al. · Nature · 1999 · 2.1K citations

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A Novel Proteolytic Cleavage Involved in Notch Signaling

Christel Brou, Frédérique Logeat, Neetu Gupta et al. · Molecular Cell · 2000 · 1.1K citations · Full text

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aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation

Ross S. Francis, Garth McGrath, Jianhua Zhang et al. · Developmental Cell · 2002 · 796 citations · Full text

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<i>FBW7</i> mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

Jennifer O’Neil, Jonathan Grim, Peter R. Strack et al. · The Journal of Experimental Medicine · 2007 · 662 citations · Full text

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Cis-interactions between Notch and Delta generate mutually exclusive signalling states

David Sprinzak, Amit Lakhanpal, Lauren LeBon et al. · Nature · 2010 · 659 citations

, , +10