Concepedia

Notch Interactions

Notch Interactions is a cell-cell signaling mechanism characterized by direct physical communication between adjacent cells through the binding of transmembrane Notch receptors to ligands of the Delta-Serrate-Lag2 family, initiating proteolytic cleavage and nuclear translocation of the receptor’s intracellular domain to regulate gene expression in developmental and homeostatic processes.

431

Publications

38.7K

Citations

2.4K

Authors

735

Institutions

Publications per year

2017–2026

82

Parents

Publications

431

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

Ilaria Rebay, R.J. Fleming, Richard G. Fehon et al. · Cell · 1991 · 774 citations

, , +9

Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila

Richard G. Fehon, Pamela J. Kooh, Ilaria Rebay et al. · Cell · 1990 · 676 citations

, , +13

Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis

Yoshiharu Miyamoto, Anirban Maitra, Bidyut Ghosh et al. · Cancer Cell · 2003 · 637 citations

, , +16

scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila

Anthony M. Brumby, Helena E. Richardson · The EMBO Journal · 2003 · 630 citations · Full text

, , +14

Fringe modulates Notch–ligand interactions

Vladislav M. Panin, Venizelos Papayannopoulos, Richa Wilson et al. · Nature · 1997 · 593 citations

, , +12

1–5 of 431

Authors

2.4K

  1. SA
    Spyros Artavanis‐Tsakonas

    Harvard University, United States

    17 publications · 3K citations

    17

    h-index

  2. AM
    Alfonso Martínez Arias

    University of Cambridge, United Kingdom

    8 publications · 706 citations

    8

    h-index

  3. SJ
    Sarah J. Bray

    University of Cambridge, United Kingdom

    8 publications · 599 citations

    8

    h-index

  4. IG
    Iva Greenwald

    Columbia University, United States

    7 publications · 980 citations

    7

    h-index

  5. RK
    Raphael Kopan

    Washington University in St. Louis, United States

    6 publications · 937 citations

    6

    h-index

1–5 of 2.4K

Institutions

735

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    32 h-index

    106 publications

    26.4K citations

  2. Harvard University

    Cambridge, United States

    23 h-index

    78 publications

    6.4K citations

  3. University of Cambridge

    Cambridge, United Kingdom

    16 h-index

    60 publications

    4.7K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    14 h-index

    48 publications

    3.3K citations

  5. Yale University

    New Haven, United States

    13 h-index

    58 publications

    13.6K citations

  6. Inserm

    Paris, France

    11 h-index

    28 publications

    2.9K citations

  7. University of Toronto

    Toronto, Canada

    11 h-index

    27 publications

    3.7K citations

  8. University of Oxford

    Oxford, United Kingdom

    10 h-index

    70 publications

    4.1K citations

1–8 of 735

Venues

  1. Development

    43 publications · 4.9K citations

    33

    h-index

  2. Journal of Biological Chemistry

    JBC · 32 publications · 3.3K citations

    31

    h-index

  3. PLoS ONE

    16 publications · 608 citations

    14

    h-index

  4. Developmental Biology

    14 publications · 827 citations

    14

    h-index

  5. Genetics

    12 publications · 726 citations

    12

    h-index

1–5