Gut · 1998 · 221 citations · 25 references
The CTLA-4 gene polymorphism is a non-HLA determinant that predisposes to coeliac disease. Whether it directly contributes to disease susceptibility or represents a marker for a locus in linkage disequilibrium with CTLA-4 needs further investigation.
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Elizabeth Tivol, Frank Borriello, Alain Schweitzer et al. · Immunity · 1995 · 2.9K citations · Full text
CTLA-4 can function as a negative regulator of T cell activation
Theresa L. Walunas, Deborah J. Lenschow, Christina Y. Bakker et al. · Immunity · 1994 · 2.2K citations
T Cell Activation, Signal Transduction, Autoimmune Disease +11
Assessing the role of HLA-linked and unlinked determinants of disease.
Neil Risch · PubMed · 1987 · 543 citations