The Journal of Experimental Medicine · 1989 · 939 citations · 16 references
Life SciencesGeneticsImmunologyHuman GeneticsImmunogeneticsMedical GeneticsAutoimmune Disease Susceptibility GenesAutoimmune DiseasesCeliac DiseaseGenetic Susceptibility To AutoimmunityHla TypingMajor Histocompatibility ComplexCeliac Disease ImmunogeneticsCeliac Disease ImmunologyCeliac Disease PathogenesisHaplotype MappingHaplotype VariationHla AllelesHla Genotype AssociationsHla Risk Alleles
Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share the same cis- or trans-encoded HLA-DQ alpha/beta heterodimer.
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