Concepedia

Synthesis and biological evaluation of a series of HIV-1 protease inhibitors

Michael P. Trova, Robert E. Babine, Randal A. Byrn, Wellington T. Casscles, Richard Hastings, Grace C. Hsu, Michael R. Jirousek, Bernard D. Johnson, S.S. Kerwar, Steven R. Schow,

Bioorganic & Medicinal Chemistry Letters · 1993 · 17 citations · 33 references

DOI

Concepts

References

33

Active human immunodeficiency virus protease is required for viral infectivity.

Nancy E. Kohl, Emilio A. Emini, William A. Schleif et al. · Proceedings of the National Academy of Sciences · 1988 · 1.3K citations · Full text

, , +17

Conserved Folding in Retroviral Proteases: Crystal Structure of Synthetic HIV-1 Protease

Alexander Wlodawer, Maria Miller, Mariusz Jaskólski et al. · Science · 1989 · 1.2K citations

, , +17

Asymmetric alkylation reactions of chiral imide enolates. A practical approach to the enantioselective synthesis of .alpha.-substituted carboxylic acid derivatives

David A. Evans, Michael D. Ennis, David J. Mathre · Journal of the American Chemical Society · 1982 · 1K citations

, , +11

Rational Design of Peptide-Based HIV Proteinase Inhibitors

Noel A. Roberts, Joseph A. Martin, Derek Kinchington et al. · Science · 1990 · 925 citations

, , +17

Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

Manuel A. Navia, Paula M.D. Fitzgerald, Brian M. McKeever et al. · Nature · 1989 · 893 citations

, , +16