Michael R. Jirousek

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Jill C. Milne, Philip Lambert, Simon Schenk et al. · Nature · 2007 · 1.7K citations · Full text

Medicine, Medicinal Chemistry, Molecular Biology +14

Vascular Endothelial Growth Factor–Induced Retinal Permeability Is Mediated by Protein Kinase C In Vivo and Suppressed by an Orally Effective β-Isoform–Selective Inhibitor

Lloyd Paul Aiello, Sven–Erik Bursell, Allen C. Clermont et al. · Diabetes · 1997 · 669 citations

Medicine, Ophthalmology, Pharmacology +15

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

Bradley A. Zinker, Cristina M. Rondinone, James M. Trevillyan et al. · Proceedings of the National Academy of Sciences · 2002 · 416 citations

Life Sciences, Endocrinology, Molecular Biology +17

SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes

Takeshi Yoshizaki, Jill C. Milne, Takeshi Imamura et al. · Molecular and Cellular Biology · 2008 · 412 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Targeted overexpression of protein kinase C β2 isoform in myocardium causes cardiomyopathy

Hisao Wakasaki, Daisuke Koya, Frederick J. Schoen et al. · Proceedings of the National Academy of Sciences · 1997 · 381 citations · Full text

Life Sciences, Cardiology, Molecular Biology +17