Michael R. Jirousek

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Jill C. Milne, Philip Lambert, Simon Schenk et al. · Nature · 2007 · 1.7K citations · Full text

Diabetes Management, Medicine, Diabetes +9

Vascular Endothelial Growth Factor–Induced Retinal Permeability Is Mediated by Protein Kinase C In Vivo and Suppressed by an Orally Effective β-Isoform–Selective Inhibitor

Lloyd Paul Aiello, Sven-Erik Bursell, Allen C. Clermont et al. · Diabetes · 1997 · 664 citations

Ocular Disease, Retinal Therapies, Vascular Permeability +18

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

Bradley A. Zinker, Cristina M. Rondinone, James M. Trevillyan et al. · Proceedings of the National Academy of Sciences · 2002 · 412 citations · Full text

SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes

Takeshi Yoshizaki, Jill C. Milne, Takeshi Imamura et al. · Molecular and Cellular Biology · 2008 · 410 citations · Full text

Targeted overexpression of protein kinase C β2 isoform in myocardium causes cardiomyopathy

Hisao Wakasaki, Daisuke Koya, Frederick J. Schoen et al. · Proceedings of the National Academy of Sciences · 1997 · 381 citations · Full text