Concepedia

Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2

Renaud Dentin, Yi Liu, Seung‐Hoi Koo, Susan Hedrick, Thomas Vargas, J. Basilio Heredia, John R. Yates, Marc Montminy

Nature · 2007 · 390 citations · 24 references

DOI

Concepts

References

24

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

Han Cho, James Mu, Jason K. Kim et al. · Science · 2001 · 1.8K citations

, , +17

Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction

Pere Puigserver, James Rhee, Jerry Donovan et al. · Nature · 2003 · 1.5K citations

, , +14

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

Stephan Herzig, Fanxin Long, Ulupi S. Jhala et al. · Nature · 2001 · 1.4K citations

, , +13

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

Seung‐Hoi Koo, Lawrence Flechner, Ling Qi et al. · Nature · 2005 · 975 citations

, , +13

The ubiquitin ligase COP1 is a critical negative regulator of p53

David Dornan, Ingrid E. Wertz, Harumi Shimizu et al. · Nature · 2004 · 708 citations

, , +12