Concepedia

Monocarboxylate Transporters 1–4 in NSCLC: MCT1 Is an Independent Prognostic Marker for Survival

Marte Eilertsen, Sigve Andersen, Samer Al‐Saad, Yury Kiselev, Tom Dønnem, Helge Stenvold, Ingvild Pettersen, Khalid Al‐Shibli, Elin Richardsen, Lill‐Tove Busund,

PLoS ONE · 2014 · 76 citations · 20 references

DOIFull text

Open access

Abstract

We provide novel information of MCT1 as a candidate marker for prognostic stratification in NSCLC. Interestingly, MCT1 shows diverging, independent prognostic impact in the cancer cell and stromal cell compartments.

References

20

Global cancer statistics

Ahmedin Jemal, Freddie Bray · CA A Cancer Journal for Clinicians · 2011 · 55K citations · Full text

The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

Andrew P. Halestrap, Nigel T. Price · Biochemical Journal · 1999 · 1.3K citations · Full text

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Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF-κB/IL-8 Pathway that Drives Tumor Angiogenesis

Frédérique Végran, Romain Boidot, Carine Michiels et al. · Cancer Research · 2011 · 772 citations

, , +20

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

Pierre Sonveaux, Tamara Copetti, Christophe J. De Saedeleer et al. · PLoS ONE · 2012 · 511 citations · Full text

, , +19

Comparison of Metabolic Pathways between Cancer Cells and Stromal Cells in Colorectal Carcinomas: a Metabolic Survival Role for Tumor-Associated Stroma

Michael I. Koukourakis, Alexandra Giatromanolaki, Adrian L. Harris et al. · Cancer Research · 2006 · 433 citations · Full text