Attenuation of LDHA expression in cancer cells leads to redox-dependent alterations in cytoskeletal structure and cell migration

On the Origin of Cancer Cells

Otto Warbürg · Science · 1956 · 13.3K citations

Medicine, Cancer Biology, Cell Biology +12

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Jung‐whan Kim, Irina Tchernyshyov, Gregg L. Semenza et al. · Cell Metabolism · 2006 · 3.9K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

On Respiratory Impairment in Cancer Cells

Otto Warbürg · Science · 1956 · 3.2K citations

Medicine, Cancer Biology, Oncology +13

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Ioanna Papandreou, Rob A. Cairns, Lucrezia Fontana et al. · Cell Metabolism · 2006 · 2.2K citations · Full text

Life Sciences, Cell Biology, Physiology +12

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

Valeria R. Fantin, Julie St‐Pierre, Philip Leder · Cancer Cell · 2006 · 1.6K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16