Lack of prostacyclin biosynthesis by aortic tissue of the chicken

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Isolation and properties of intermediates in prostaglandin biosynthesis

D.H. Nugteren, E. Hazelhof · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · 1973 · 795 citations

Life Sciences, Biochemistry, Molecular Biology +8

Further studies on the enzymatic conversion of prostaglandin endoperoxide into prostacyclin by porcine aorta microsomes

John A. Salmon, Derek R. Smith, Roderick J. Flower et al. · Biochimica et Biophysica Acta (BBA) - Enzymology · 1978 · 304 citations

Life Sciences, Biochemistry, Cellular Metabolism +11

Metabolism of prostaglandin endoperoxide in animal tissues

F.F. Sun, Justin Chapman, James C. McGuire · Prostaglandins · 1977 · 287 citations

Life Sciences, Biochemistry, Pharmacology +10

Comparative aspects of prostaglandin biosynthesis in animal tissues

Emanuel Christ, D. A. van Dorp · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · 1972 · 268 citations

Life Sciences, Biochemistry, Metabolism +9