Concepedia

Prostacyclin Biosynthesis

Prostacyclin Biosynthesis is a biochemical pathway within eicosanoid biosynthesis that catalyzes the formation of prostacyclin from prostaglandin H2 via the action of prostacyclin synthase, distinguishing it from other prostanoid biosynthetic routes by its specific enzymatic conversion and physiological role in vasodilation and platelet inhibition.

3.1K

Publications

198.1K

Citations

8.4K

Authors

1.5K

Institutions

Publications per year

2017–2026

33

Parents

Publications

3.1K

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

, , +10

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

, , +16

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

Mats Hámberg, Jan Olof Svensson, B Samuelsson · Proceedings of the National Academy of Sciences · 1975 · 3.1K citations · Full text

, , +14

Aspirin Selectively Inhibits Prostaglandin Production in Human Platelets

J. Bryan Smith, A.L. Willis · Nature New Biology · 1971 · 1.5K citations

, , +14

Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2

Brendan McAdam, Francesca Catella-Lawson, Issam A. Mardini et al. · Proceedings of the National Academy of Sciences · 1999 · 1.3K citations

, , +13

1–5 of 3.1K

Authors

8.4K

  1. GA
    Garret A. FitzGerald

    University of Pennsylvania, United States

    36 publications · 9.1K citations

    32

    h-index

  2. BS
    Bengt Samuelsson

    Karolinska Institutet, Sweden

    33 publications · 6.6K citations

    31

    h-index

  3. SM
    Salvador Moncada

    Wellcome Trust, United Kingdom

    30 publications · 9.2K citations

    24

    h-index

  4. PN
    Philip Needleman

    Washington University in St. Louis, United States

    26 publications · 4.3K citations

    24

    h-index

  5. MH
    Mats Hámberg

    Karolinska Institutet, Sweden

    25 publications · 7.1K citations

    23

    h-index

1–5 of 8.4K

Institutions

1.5K

  1. Vanderbilt University

    Nashville, United States

    41 h-index

    207 publications

    39.7K citations

  2. Karolinska Institutet

    Stockholm, Sweden

    40 h-index

    162 publications

    31.9K citations

  3. Washington University in St. Louis

    St Louis, United States

    31 h-index

    123 publications

    18.5K citations

  4. Wellcome Trust

    London, United Kingdom

    27 h-index

    94 publications

    37.8K citations

  5. Harvard University

    Cambridge, United States

    26 h-index

    97 publications

    6.9K citations

  6. Inserm

    Paris, France

    26 h-index

    160 publications

    5.8K citations

  7. The University of Texas Health Science Center at Houston

    Houston, United States

    22 h-index

    86 publications

    3.5K citations

  8. University of Konstanz

    Konstanz, Germany

    22 h-index

    79 publications

    7.7K citations

1–8 of 1.5K

Venues

  1. Prostaglandins

    282 publications · 14.4K citations

    66

    h-index

  2. Journal of Biological Chemistry

    JBC · 79 publications · 12.5K citations

    58

    h-index

  3. PubMed

    Repository · 286 publications · 9.9K citations

    49

    h-index

  4. Journal of Clinical Investigation

    JCI · 55 publications · 8.7K citations

    46

    h-index

  5. 44

    h-index

1–5