Philip Needleman

Nitric oxide activates cyclooxygenase enzymes.

Daniela Salvemini, Thomas P. Misko, Jaime L. Masferrer et al. · Proceedings of the National Academy of Sciences · 1993 · 1.4K citations

Inflammation, Pge2 Production, Redox Signaling +12

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.

Jianmin Fu, Jaime L. Masferrer, Karen Seibert et al. · Journal of Biological Chemistry · 1990 · 941 citations · Full text

Lipid Peroxidation, Immunology, Thromboxane A2 +22

Triene prostaglandins: Prostacyclin and thromboxane biosynthesis and unique biological properties

Philip Needleman, Amiram Raz, Mark S. Minkes et al. · Proceedings of the National Academy of Sciences · 1979 · 783 citations · Full text

Bioactive Cardiac Substances: Potent Vasorelaxant Activity in Mammalian Atria

Mark G. Currie, David M. Geller, Barbara R. Cole et al. · Science · 1983 · 710 citations

Bioactive Cardiac Substances, Molecular Pharmacology, Cardiac Muscle +14

Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides

Philip Needleman, Salvador Moncada, S Bunting et al. · Nature · 1976 · 525 citations

Thrombopoiesis, Thrombosis, Biochemistry +12