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Optimization of the β-Aminoester class of factor Xa inhibitors. part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity

Kevin R. Guertin, Charles J. Gardner, Scott I. Klein, Allison L. Zulli, Mark Czekaj, Yong Gong, Alfred P. Spada, Daniel L. Cheney, Sebastian Maignan, J.P. Guilloteau,

Bioorganic & Medicinal Chemistry Letters · 2002 · 52 citations · 10 references

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10

Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion.

Erling Falk · Circulation · 1985 · 1.1K citations

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Evidence for a rebound coagulation phenomenon after cessation of a 4-hour infusion of a specific thrombin inhibitor in patients with unstable angina pectoris

Herman K. Gold, F Torres, Harry D. Garabedian et al. · Journal of the American College of Cardiology · 1993 · 180 citations

, , +14

Identification and Initial Structure−Activity Relationships of a Novel Class of Nonpeptide Inhibitors of Blood Coagulation Factor Xa

Scott I. Klein, Mark Czekaj, Charles J. Gardner et al. · Journal of Medicinal Chemistry · 1998 · 39 citations · Full text

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Factor Xa Inhibitors as Novel Antithrombotic Agents: Facts and Perspectives

Brigitte Kaiser, Jörg Hauptmann · Cardiovascular Drug Reviews · 1994 · 30 citations

, , +12

Pharmacological Characterization of a Novel Factor Xa Inhibitor, FXV673

Valeria Chu, Karen Brown, Dennis Colussi et al. · Thrombosis Research · 2001 · 28 citations

, , +9