Crystal Structures of Human Factor Xa Complexed with Potent Inhibitors

S. Maignan, J.P. Guilloteau, Stéphanie Pouzieux, +7

Journal of Medicinal Chemistry

X-ray CrystallographyCrystal StructureProtein AssemblyMolecular BiologyPharmaceutical Chemistry +19

Synthesis of heparin-sepharoses and their binding with thrombin and antithrombin-heparin cofactor

I. Danishefsky, F. Tzeng, M. Ahrens, +1

Thrombosis Research

ThrombopoiesisThrombosisAntithrombin-heparin CofactorBiochemistryBlood Platelet +8

Optimization of the β-Aminoester class of factor Xa inhibitors. part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity

Kevin R. Guertin, Charles J. Gardner, Scott I. Klein, +16

Bioorganic & Medicinal Chemistry Letters

ThrombosisMedicinal ChemistryBiochemistryβ-Aminoester ClassPart 2 +8

Acyclic diastereoselection as a synthetic route to quassinoids: a Claisen rearrangement based strategy for bruceantin

Frederick E. Ziegler, Scott I. Klein, Uttam Pati, +1

Journal of the American Chemical Society

Synthetic RouteBioorganic ChemistryAltmetric Attention ScoreAcyclic DiastereoselectionOrganic Chemistry +16

Effect of heparin modification on its activity in enhancing the inhibition of thrombin by antithrombin III

I. Danishefsky, M. Ahrens, Scott I. Klein

Biochimica et Biophysica Acta (BBA) - General Subjects

ThrombopoiesisThrombosisBiochemistryBlood PlateletMedicine +8

Identification and Initial Structure−Activity Relationships of a Novel Class of Nonpeptide Inhibitors of Blood Coagulation Factor Xa

Scott I. Klein, Mark Czekaj, Charles J. Gardner, +12

Journal of Medicinal Chemistry

Vitro PotencyPharmacotherapyInitial Structure−activity RelationshipsChemical BiologyPharmaceutical Chemistry +18

Antithrombotic efficacy of RPR208566, a novel factor Xa inhibitor, in a rat model of carotid artery thrombosis

Christopher L. Heran, Suzanne R. Morgan, Charles Kasiewski, +9

European Journal of Pharmacology

ThrombosisVascular DiseaseCardiovascular DiseaseBlood PlateletMedicine +11

Practical routes to two functionalized decalones for the synthesis of quassinoids

Frederick E. Ziegler, Ki Jun Hwang, John F. Kadow, +3

The Journal of Organic Chemistry

Combinatorial ChemistryEngineeringAltmetric Attention ScoreBibliometricsOrganic Chemistry +20

Development of high-affinity 5-HT3 receptor antagonists. 2. Two novel tricyclic benzamides

Raymond D. Youssefyeh, H. F. Campbell, John Airey, +6

Journal of Medicinal Chemistry

Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides

Raymond D. Youssefyeh, H. F. Campbell, Scott I. Klein, +6

Journal of Medicinal Chemistry