Factor Xa Inhibitors as Novel Antithrombotic Agents: Facts and Perspectives

Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.

Jeffrey I. Weitz, Monika Hudoba, David Massel et al. · Journal of Clinical Investigation · 1990 · 1.1K citations · Full text

Tick Anticoagulant Peptide (TAP) Is a Novel Inhibitor of Blood Coagulation Factor Xa

Lloyd Waxman, Donna Smith, Karen E. Arcuri et al. · Science · 1990 · 413 citations

Tick Anticoagulant Peptide, Novel Inhibitor, Antiparasitic Agent +24

Isolation and characterization of antistasin. An inhibitor of metastasis and coagulation.

Tuszynski Gp, Tatiana B. Gasic, G Gasic · Journal of Biological Chemistry · 1987 · 175 citations · Full text

Antistasin, a Leech-derived Inhibitor of Factor Xa

Christopher T. Dunwiddie, Nancy A. Thornberry, Herbert G. Bull et al. · Journal of Biological Chemistry · 1989 · 156 citations · Full text

Conjunctive enhancement of enzymatic thrombolysis and prevention of thrombotic reocclusion with the selective factor Xa inhibitor, tick anticoagulant peptide. Comparison to hirudin and heparin in a canine model of acute coronary artery thrombosis.

Gary R. Sitko, Denise Ramjit, Inez I. Stabilito et al. · Circulation · 1992 · 131 citations · Full text