Rac1 changes the substrate specificity of γ-secretase between amyloid precursor protein and Notch1

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

Anne J. Ridley, Hugh F. Paterson, Caroline L. Johnston et al. · Cell · 1992 · 3.6K citations

Signal Transduction, Developmental Biology, G Protein-coupled Receptor +8

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

Bart De Strooper, Wim Annaert, Philippe Cupers et al. · Nature · 1999 · 2.1K citations

Protein Secretion, Protein Function, Signal Transduction +8

γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase

Chang-Yuan Ni, M. Paul Murphy, Todd E. Golde et al. · Science · 2001 · 847 citations

Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation

Gwendolyn T. Wong, Denise Manfra, Frederique M. Poulet et al. · Journal of Biological Chemistry · 2004 · 715 citations · Full text

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

Philippe Marambaud · The EMBO Journal · 2002 · 676 citations · Full text

Protein Secretion, Signal Transduction, Cell Signaling +15