Bioactive Potential of Medicinal Plants from Western Ghats Region, India

Abstract

Methanol extracts of Elaeocarpus, E. serratus, E. tuberculatus (Elaeocarpaceae), Catunaregam uliginosa, C. spinosa (Rubiaceae), Elaeagnus conferta (Elaeagnaceae), Evodia lunu-ankenda (Rutaceae), Glycosmis arborea (Rutaceae), Melastoma malabathricum. (Melastomataceae), and Smilax zeylanica (Liliaceae) leaves were screened for antioxidant, anti-inflammatory, and cytotoxicity to Vero cell lines. 1,1-diphenyl-2-picrylhydrazyl and 2-2′-azinobis-(3-ethylbenzthiazoline-6-sulfonic acid radical scavenging capacities were identified C. spinosa and E. tuberculatus. Anti-inflammatory capacity with lipoxygenase and human cyclooxygenase-2 inhibition for E. tuberculatus and E. serratus was recorded. The extracts prevented DNA damage by hydroxyl radicals produced by Fenton reagent. Cell cytotoxicity studies revealed S. zeylanica and E. tuberculatus with potent cytotoxicity to Vero cells.